Retinoid
Retinol
An over-the-counter retinoid that promotes cell turnover and may support collagen production. Strong evidence for wrinkles and texture, but requires patience and careful introduction.
topicalanti-ageingretinoid
Last reviewed: March 2026 · Our methodology
What It Does
Retinol is converted to retinoic acid in the skin, where it accelerates cell turnover, may stimulate collagen synthesis, and helps improve skin texture and fine lines over time. It is the most widely studied OTC anti-ageing ingredient.
Best Use Cases
- Fine lines and wrinkles
- Skin texture and roughness
- Mild acne (comedonal)
- Some improvement in pigmentation over time
Who May Benefit Most
Adults concerned with signs of ageing, rough texture, or mild acne. Not ideal for very sensitive or barrier-compromised skin without careful introduction.
Cautions
Retinol causes irritation, dryness, and peeling during the adjustment period (retinisation). Start with a low concentration (0.25-0.3%) 2-3 nights per week. Always use sunscreen the following day. Avoid during pregnancy.
Common Mistakes
- Starting with a high concentration too quickly
- Applying to damp or freshly-exfoliated skin
- Skipping sunscreen during the day
- Combining with other strong actives (AHA, BHA, benzoyl peroxide) in the same routine step without building tolerance
Combines Well With
- Niacinamide (well tolerated together)
- Hyaluronic acid and ceramides (to support barrier during retinisation)
- Sunscreen (essential)
May Combine Poorly With
- AHA/BHA exfoliants in the same PM step (use on alternate nights)
- Benzoyl peroxide (may degrade retinol on contact)
- Vitamin C at low pH in the same step (use AM/PM split instead)
Realistic Timeline
Initial retinisation (dryness, peeling) may occur in weeks 1-4. Texture improvements often visible by 8-12 weeks. Anti-ageing benefits build over 3-6+ months of consistent use.
Disclaimer
Retinol can cause significant irritation if misused. Start low and slow. Consult a dermatologist, especially if you have sensitive skin or are considering prescription retinoids.